Fagopyrum esculentum Moench is one of the vital unattended crops andis grown as a minor grain crop in the Indian Himalayas, especially in the high-altitude areas. The plant was studied to know the level of toler-ance to drought stress. Seeds of F. esculentumwere sown in nursery beds and with the appearance of first leaf; seed-lings were transferred to ceramic pots filled with mixture of soil and sand. Drought stress was imposed by watering while weighing method was used to control water potential to meet the experimental requirements. Different water potentials(-0.01, -0.02, -0.03, -0.04, -0.05, -0.06 and -0.07MPa) wereachievedafter 15 days of transplanting the seedlings to pots. Response of enzymatic antioxidants to drought stress was studied in leaves and roots of F. esculentumat an interval of 30, 45, 60 and 75 days of plant growth. F. esculentumhas a protection mechanism against oxidative damage by maintaining higher activities of enzymatic antioxidants (superoxide dismutase, catalase and peroxidase).