Morphological and Skeletal Malformations Induced by Gabapentin in Rat Fetuses and their Amelioration by Ginger

Author(s): Gamal M. Badawy, Marwa N. Atallah and Saber A. Sakr

The present study aimed to investigate the possible morphological and skeletal fetotoxicity of the new antiepileptic drug, gabapentin (GBP) during the organogenesis phase of the rat embryonic development and to examine the possible ameliorative role of ginger (Zingiber officinale). Morphologically, there was evident growth retardation and a high frequency of malformations in the skin, head, trunk, limbs and tail of fetuses maternally injected with GBP. Skeletal investigation revealed that rat fetuses of the GBP group exhibited delayed ossification and various skeletal malformation. Limb deformities was the most prominent feature observed followed by coastal malformations, vertebral deformities, skull anomalies and sternal defects, respectively. The most evident skull malformation was maxillary and mandibular hypoplasia. Ginger extract caused an evident decrease in GBP-induced fetotoxicity at the investigated parameters. In conclusion, treatment with GBP should be approached with highly caution during pregnancy and ginger is recommended to be taken in parallel for its ameliorative role in this regard.


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