Parkinson's Disease and Depression-Together or Apart: A Review

Author(s): Atul Kabra, Shivani Thakur, Rohit Sharma, Ruchika Garg and Uttam Singh Baghel

Depression is a standout amongst the most widely recognized non-motor side effects in Parkinson's disease (PD). Depression in PD is related with a progressively quick decline in motor and as well as intellectual ex-ecution. The frequency of PD increments with age and many age-related comorbid conditions, including cardiovas-cular ailment. The pathophysiological mechanism involved in depression in PD includes abnormalities of serotoner-gic, noradrenergic and dopaminergic functions. The utilization of serotonin reuptake inhibitors and tricyclic antide-pressants in the management of depression in PD is boundless in clinical practice. Dopamine agonists can likewise be powerful in the management of mild depression. An online search for information has been conducted on several articles, including Web of Science, PubMed, Scopus, Bentham Science, Science Direct, Springer, Google Scholar, and other allied databases, from January 1959 to December 2018. This review includes in-depth information about the risk factors, pathophysiology, pharmacological, non-pharmacological and phytotherapeutic approach for the treat-ment of depression in PD This review can be used for future research as well as for clinical purposes.


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