Synthesis, Characterization and Antimicrobial activity of bis(?-aminobutyrohydroxamate)oxovanadium(IV)

Author(s): Reena Sharma

The complex [VO(γ-C3H8NCONHO)2] (I) has been synthesized by the reaction of VOSO4.5H2O with bimolar amounts of potassium-γ-aminobutyrohydroxamate(Kγ-ABH)in methanol and characterized by elemental analyses, molar conductance and IR and ESR spectral. The molecular modeling dynamics of the complex suggest a square pyramidal geometry around vanadium. The antimicrobialactivities of the newly synthesized complex and respective potassium hydroxamate ligand have been screened in vitro against six bacterial strains viz.Staphylococcus aureus,Staphylococcus epidermidis, Escherichia coli,Klebsiella pneumoniaeSalmonella typhi.and S. paratyphiand three fungal strains viz. A. niger, B. fulva andM. circinelloideshas been assayed by MIC method. The complex hasimproved antimicrobial activity compared to free ligand


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