Short Communication - (2022) Volume 10, Issue 6

Sub-Atomic Elements Reenactment of SiRNA Epitomized in Carbon Nanotube

Mehran Ameri*
*Correspondence: Mehran Ameri, Department of Medical Sciences, Shiraz University of Medical Sciences, Iran, Email:

Author info »


Carbon nanotubes (CNTs) are one of the most widely used nanomaterials in the biomedical field. Over the past years, CNTs have certainly distinguished themselves by improving planning frameworks for a variety of biosensors, imaging, disease therapy, tissue design, and drug delivery. Carbon nanotubes are made by moving a sheet of graphene upwards. Furthermore, they can be Single-Walled Carbon Nanotubes (SWNTs) or Multi-Walled CNTs (MWCNTs). Due to their needle-like structure, CNTs can permeate the cytoplasmic membrane of cells without affecting cell passage and can then be included as transporters in drug delivery systems.


Recently, carbon nanotubes have implicated analysts in low-interfering RNA (siRNA) transport due to their shape, which can protect siRNAs from degradation. Certain quality intelligibility is reduced by the activity of doubly applied RNA. Intercellular interaction known as RNA occlusion. Protein binding stops when the siRNA binds to the appropriate site on the mRNA. After hybridization of siRNA and mRNA, the RNA-initiated quiescent complex is activated. A critical test when using siRNA-based therapeutics is planning an effective delivery framework. It is possible to use siRNA for quality assurance, provided that the siRNA can be embedded into cells without damaging it. Several delivery scaffolds have recently been used to achieve this goal, including polymer-mediated, peptide-based and lipid-based delivery scaffolds. When a CNT-based delivery scaffold is used, the siRNA separates from the carbon nanotubes after transfection into target cells. SiRNA can be bound or adsorbed to the outer layer of carbon nanotubes. In any case, incorporating siRNA into CNTs can protect them from environmental damage such as enzymatic degradation. In addition, two important variables, including temperature and CNT width, can fundamentally influence siRNA delivery using CNTs. In this review, we have focused on typical siRNAs in carbon nanotubes using atomic elemental replication.

Compare the root mean square deviation (RMSD) values to the siRNA movement at temperatures between 300 and 330K. All siRNA particles were included to obtain the RMSD. According to the development pace of RMSD, the binding of siRNA particles with CNT and water particles is fixed at 300ps at temperature of 300-320K, while the RMSD of siRNA increases with time at temperature of 330K. Normal RMSD development is seen in the siRNA-scaffold.

SiRNAs detect comparable RMSDs at 300K and 310K, with typical RMSDs of 7.3 Å and 7.6 Å at these temperatures, respectively. When the temperature is extended to 320K, siRNA encounters a typical RMSD of 9.6 Å and the value increases to 14.0 Å at 330 K temperature. Changes in normal RMSD with temperature indicate differences in siRNA structure at elevated temperatures. The difference in siRNA structure is significant due to the increase in nuclear energy at elevated temperatures.


The diversity of RMSD at different temperatures indicates that the siRNA particles inside the nanotubes are more stable at low temperatures. When the temperature of the scaffold is increased, siRNA encounters a diversity of carbon nanotubes. Due to the pace of RMSD development, it has been hypothesized that siRNA particles will detect higher dispersion coefficients at higher temperatures. This property can be used to control the imaging of siRNA inside carbon nanotubes. The expected energies of siRNAs were registered to assess the reliability of the particles at various temperatures. The energy potential of siRNAs is related to the van der Waals.



Conflict of Interest

The author’s declared that they have no conflict of interest.


Author Info

Mehran Ameri*
Department of Medical Sciences, Shiraz University of Medical Sciences, Iran

Received: 30-Nov-2022, Manuscript No. AJABS-22-84776; , Pre QC No. AJABS-22-84776 (PQ); Editor assigned: 02-Dec-2022, Pre QC No. AJABS-22-84776 (PQ); Reviewed: 16-Dec-2022, QC No. AJABS-22-84776; Revised: 21-Dec-2022, Manuscript No. AJABS-22-84776 (R); Published: 28-Dec-2022, DOI: 10.33980/ajabs.2022.v10i06.0030

Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Get the App