Pancreatic Adenocarcinoma: How good are the Genetically Engineered Mouse Models: A Review

Author(s): Udayan Bhattacharya

Pancreatic Adenocarcinoma, the most common form of pancreatic cancer, is also one of the deadliest. Though a very complex and multilayer molecular malfunctioning initiate the disease yet, there are some basic genetical mutations on some specific genes that are been identified as the most likely cause of initiation of this type of cancer. On the other hand, mouse models are days old model systems that have been used for better understanding of the molecular mechanism underlying a number of complex diseases such as cancer. In this review the author tried to focus on the significance of different available genetically engineered mouse model which are helpful to understand the molecular pathogenesis of this disease.


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